neocortical network activities negative feedback over a wide dynamic range of Localized adenosine signaling provides fine - tuned

نویسندگان

  • Mark J. Wall
  • Magnus J. E. Richardson
چکیده

publishes original articles on the function of the nervous system. It is published 12 times a year Journal of Neurophysiology

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Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.

Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there is dense A1 receptor expression in the neocortex. Using electrophysiology, bi...

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تاریخ انتشار 2015